This document describes a 3D sponge or scaffold made from Poly Vinyl Alcohol (PVA), sodium alginate, green tea extract, and aloe vera. This 3D sponge is biocompatible, non-toxic, and stable, making it suitable for use as a drug and diagnostic delivery agent. Additionally, the biocompatible 3D sponge exhibits enhanced antioxidant activity. The document also outlines a process for synthesizing this biocompatible 3D sponge.
Figure (1) is a digital picture of blank (+)polyvinyl alcohol(+)sodium alginate(-)green tea(-) aloe vera sponge solution casted in well plate; and it is a digital picture of (+)polyvinyl alcohol(+) sod alginate(+)green tea (+)aloevera sponge solution casted in well plate; (3) illustrates SEM images of sponge blank (+)polyvinyl alcohol(+)sodium alginate(-)green tea(-) aloe vera at different resolution
- Post-surgery therapies for cancer like chemotherapy can damage healthy tissue and struggle to specifically target cancer cells. While targeted drug delivery systems are being explored, there's a gap in addressing intraoperative bleeding, especially in difficult-to-reach areas during surgery. Existing methods like thermal or mechanical approaches have limitations.
- Therefore, developing a new cancer treatment system that combines chemotherapy with effective bleeding control during surgery has the potential to significantly improve post-operative cancer care.
- Sodium alginate’s hydrophilic nature helps maintain a moist environment conducive to wound healing.
- The porous structure of the sponge mimics the extracellular matrix, supporting cell attachment, growth, and tissue regeneration.
- The sponge's pH-sensitive properties can be exploited for diagnostic purposes, such as monitoring wound pH to assess infection or healing progress.
- PVA provides the sponge with the necessary mechanical strength to withstand handling and application without breaking down.
The 3D sponge prototype has been developed using biocompatible and biodegradable materials including PVA, sodium alginate, green tea extract, and aloe vera. It demonstrates properties like mechanical stability, pH-sensitivity, and enhanced wound healing.
The patent is granted
1
- By enhancing healing rates and reducing complications, the sponge contributes to better patient outcomes and shorter recovery times.
- The biodegradable nature of the sponge materials ensures that it breaks down into non-toxic components over time, reducing environmental impact.
Healthcare and Biomedical: Can be used in controlling post-operative hemorrhage, delivery systems, absorbable sponges, wound healing and many more applications.
Geography of IP
Type of IP
202121015614
446704