This invention pertains to a biomimetic three-dimensional hydrogel- based scaffold specifically designed for tissue engineering. It utilizes a novel fabrication method that includes the use of a composite gel in extremely cold conditions (cryogenic environment) to create a structurally sound and highly porous scaffold conducive to cell growth and tissue regeneration.
Figure (1) 3D-printed biomimetic bone scaffold demonstrating controlled porosity and patient- specific geometry; (2) Schematic representation of the hierarchical nanocomposite structure of biomimetic bone grafts;(3) SEM image of a cross-section of the 3D printed biomimetic bone graft.
Traditional scaffolds used in tissue engineering often struggle with mechanical stability and precise control over porosity, which are critical for effective cell integration and tissue growth. These challenges limit their application in regenerative medicine, particularly for load-bearing tissues.
Enhanced Mechanical Properties: Provides significant load-bearing capabilities, suitable for a variety of regenerative medicine applications due to
-Cryogenic 3D Printing: Employs a cryogenic environment during the 3D printing process to maintain the structure’s integrity
-Tri-layered Composite: Incorporates multiple layers of natural and synthetic materials to enhance biocompatibility and mechanical strength.
Improved Cellular Integration: Enables better cell infiltration, enhancing tissue integration and regeneration due to
-Controlled Porosity: Achieves variable porosity through sophisticated layering and post-processing techniques, optimizing the scaffold for different tissue types.
- Versatility in Application: Can be customized for different types of tissues by adjusting the porosity and material composition.
A bone mimicking 3D printed scaffold with hard PCL shell outside and soft bioactive gel inside. The hard shell mimics the cortical bone while the soft gel resembles the bone marrow. The hard shell is also coated with a thin layer of hydrogel from outside for better initial attachment with natural tissue. The complete composite is biocompatible and biodegradable and can be customized according to patient injury.
The technology has been successfully developed and demonstrated through lab-scale 3D printing of biomimetic hydrogel-based scaffolds with controlled porosity and tailored mechanical properties. The scaffolds are fabricated using cryogenic 3D printing, and the tri-layered structure has been tested for its structural integrity, biocompatibility, and support for cellular integration. Prototype scaffolds have been customized for patient-specific geometries and evaluated for use in bone and tissue regeneration, demonstrating promising results in simulated and in vitro environments.
4
This technology offers improved treatment possibilities for conditions requiring tissue regeneration, potentially enhancing outcomes in severe or chronic cases. By advancing scaffold design, it contributes meaningfully to the field of biomedical engineering, enabling more effective and adaptable solutions for tissue repair and organ support. In the long term, its adoption could help reduce healthcare costs by increasing the success rate of regenerative therapies and minimizing the need for repeated surgical interventions.
- Regenerative Medicine: Ideal for creating scaffolds that support the regeneration of complex tissues, including musculoskeletal and vascular tissues.
- Biomedical Research: Provides a versatile platform for studying tissue growth and response to different biomaterials.
- Pharmaceutical Testing: Used in drug discovery and testing to evaluate cellular responses to pharmaceutical compounds in a 3D environment
Geography of IP
Type of IP
202021048205
436414