This invention presents a novel biomimetic three-dimensional scaffold tailored for patient-specific tissue injuries. It utilizes advanced 3D printing and coating techniques (particularly freeze-drying process) with a biomimetic composite, enhancing scaffold integration and effectiveness in tissue regeneration. This scaffold is primarily designed for applications in regenerative medicine, providing structural and mechanical support while promoting cellular activities necessary for tissue healing.
Figure (1) Cross-sectional SEM image showing the macroscopic architecture of the scaffold with gel coating; (2) Schematic illustration of the fabrication process for the biomimetic hybrid scaffold; (3) Photographic image of the 3D printed biomimetic scaffold showing its macroscopic architecture.; (4) Progressive gel deposition observed at the transition zone during robotic partial coating; (5) Progressive gel deposition observed at the transition zone during robotic partial coating.
Current scaffold technologies often fail to provide a tailored environment that actively supports the healing and integration of tissue, particularly in complex or irregularly shaped tissue defects.
- The cases which involve the use of autografts (low risk of rejection and minimal probability of infections) are limited by the availability of donor tissue and donor site morbidity.
- For cases that have large defect to repair, artificial materials (titanium, stainless steel) are used which closely match the mechanical properties of the native tissues but are prone to tissue deterioration due to corrosion.
- The use of natural polymers limits their application to soft tissues due to poor mechanical properties.
Specific Design: Integrates various characteristic features and offer enhanced mechanical strength, biocompatibility, and biodegradability through
-Dual Material Composition: Incorporates two distinct materials with different properties; one for structural support and slower degradation, and another for enhanced biocompatibility and faster resorption.
-Gradient Porosity: Features a gradient in porosity from less porous at the periphery to more porous centrally, mimicking natural bone architecture to support new tissue growth and nutrient transfer.
- Patient-Specific Design: Utilizes imaging data (e.g., CT scans) to customize the scaffold specifically to the patient's anatomy, ensuring a perfect fit and optimal function, to ensure anatomical compatibility, enhancing the effectiveness of surgical interventions and tissue integration.
- 3D Printing and Freeze-Drying Techniques: The scaffold employs a combination of 3D printing and freeze-drying to create a structure that is both strong and biologically active.
3D printed biodegradable and biocompatible hard scaffold with bone-like gradient porosity architecture based on patient specific tissue injury that provides long-term support for new bone regeneration. This framework is robotically coated with soft bioactive gel that helps, which endorses faster bone generation during the early phase.
The technology has been successfully developed and demonstrated through lab-scale 3D printing of biomimetic hydrogel-based scaffolds with controlled porosity and tailored mechanical properties. The scaffolds are fabricated using cryogenic 3D printing, and the tri-layered structure has been tested for its structural integrity, biocompatibility, and support for cellular integration. Prototype scaffolds have been customized for patient-specific geometries and evaluated for use in bone and tissue regeneration, demonstrating promising results in simulated and in vitro environments.
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By improving the efficacy of surgical repairs and regeneration of complex tissues, this technology has the potential to significantly reduce recovery times and improve the outcomes for patients undergoing tissue repair surgeries. The patient-specific design minimizes the risk of complications and enhances the healing process, contributing to better overall healthcare efficiency and patient satisfaction.
- Regenerative Medicine: Ideal for repairing complex tissue injuries and supporting tissue regeneration in orthopaedics, particularly in cases of non-uniform bone defects.
- Surgical Implants: Can be used as implants in surgeries requiring highly specific shapes and properties that traditional implants cannot provide.
- Research and Development: Provides a platform for studying the interactions between different biomaterials and human tissues, enhancing the understanding of tissue regeneration processes.
Geography of IP
Type of IP
202021050970
527963