The invention discloses a novel pelvic floor support mesh designed specifically for the repair and regeneration of female pelvic tissue. This mesh incorporates a unique blend of bioresorbable nanofibers made from polycaprolactone (PCL) and citric acid- modified polyethylene-glycol (PEG), which are integrated using electrospinning techniques. The mesh is tailored to match the mechanical properties of the pelvic floor, promoting extra cellular matrix (ECM) formation while being soft, flexible, and possessing antibacterial properties due to the inclusion of zinc oxide nanoparticles.
Figure (1) Soft, Resorbable Nanofibrous Mesh for Pelvic Organ Prolapse
Pelvic organ prolapse is a significant health issue affecting perimenopausal and postmenopausal women, primarily due to the weakening of pelvic floor tissues. Traditional treatment, which include synthetic non-resorbable meshes, often lead to complications such as inflammation, erosion, and pain due to poor biocompatibility and mechanical mismatch with natural tissues. This invention aims to overcome these challenges by introducing a biocompatible, bioresorbable mesh that integrates seamlessly with human tissue and supports natural healing processes.
The innovative combination and the method of fabrication make this mesh uniquely effective for pelvic floor repair due to the use of
-Bioresorbable Nanofiber: Utilizes a composite of PCL and citric acid-grated PEG, enhancing biocompatibility and enabling gradual degradation aligned with natural tissue healing
-Electrospinning Fabrication: Employs electrospinning to create a non-woven mesh structure that promote effective ECM production and cell integration
- The biodegradable nature allows the mesh to support the pelvic area temporarily, gradually integrating with the body’s tissue before safely absorbing.
- Antibacterial Properties: Incorporates zinc oxide nanoparticles to provide inherent antibacterial effects, reducing the risk of infections post-surgery
Conforms to the natural shapes and movements of the human body, minimizing discomfort and complications associated with stiffer materials due to
-Mechanical Compatibility: Engineered to mimic the elasticity and strength of the pelvic floor, ensuring support without causing additional stress to surrounding tissues
The prototype consists of a soft, resorbable nanofibrous mesh made from biodegradable polymers infused with antibacterial agents. It has been tested for mechanical strength, degradation rate, and antibacterial efficacy.
The technology is in the advanced prototyping stage, with successful initial testing. Further clinical trials are planned to ensure efficacy and safety before commercial release.
5
This invention has the potential to significantly improve the quality of life for women undergoing pelvic floor repairs by reducing surgical complications and promoting faster recovery. By providing a mesh that degrades in harmony with the body’s healing process and reduces the risk of infection, the technology sets a new standard in the treatment of pelvic floor disorders, aligning with advances in women’s health and surgical care
- Gynecological Surgery: Primarily used for treating pelvic organ prolapse in perimenopausal and postmenopausal.
- Hernia Repair: Applicable in the surgical repair of hernias due to its strength and flexibility.
- Tissue Engineering: Serves as a scaffold in regenerative medicine, facilitating the growth and regeneration of biological tissues.
Geography of IP
Type of IP
202021049256
469385