This patent describes a coated root form endosseous dental implant that induces proprioception, enhancing the implant’s ability to mimic natural tooth function. The implant is coated with a polymer nanofiber matrix consisting of biodegradable and biocompatible synthetic and natural polymers, along with a neurogenesis and angiogenesis promoter, to facilitate osseointegration and neural regeneration.
Figure (1) Schematic and experimental images of a root-form dental implant with a nanofiber- coated surface designed to enhance osseointegration, including in vivo evaluation in a rabbit tibia model. While this figure demonstrates bone-implant integration, neural regeneration and proprioceptive function studies are proposed separately.
Traditional dental implants often lack the ability to induce proprioception, which is the sensation and ability to feel pressure and texture, similar to natural teeth. This absence can lead to improper bite force distribution and potential damage to the implant or surrounding oral structures. Additionally, conventional coatings on implants suffer from issues such as poor adhesion, low tensile strength, and inadequate osseointegration.
- Polymer Nanofiber Matrix: Incorporates a blend of synthetic polymers like polycaprolactone (PCL) and natural polymers like gelatin type A.
- Neurogenesis and Angiogenesis Promoter: Includes factors such as fibroblastic growth factor (FGF) and platelet-rich plasma (PRP) to promote neural and vascular tissue growth.
- Proprioception Induction: Unique in its ability to induce proprioception, mimicking natural periodontal ligament function.
- Enhanced Osseointegration: The coating improves osseointegration by providing a conducive environment for bone and tissue integration around the implant.
Prototypes have demonstrated a uniform coating thickness of 200 nm, achieved using electrospinning with specific conditions (0.25 ml/hr dispensing rate, 10 cm needle-collector distance, 15 V applied voltage, and 50 rpm rotational speed). These prototypes have shown effective osseointegration and neural differentiation in preclinical testing.
This technology is in the prototype stage, showing promising preclinical results in enhancing osseointegration and inducing proprioception. Initial tests confirm improved bone integration and neural differentiation, indicating readiness for further clinical trials and potential clinical application.
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This technology promises to improve the quality of life for dental implant patients by providing implants that not only integrate better with bone but also restore sensory functions lost with traditional implants. It can lead to quicker recovery times, reduced risk of implant failure, and overall better oral health outcomes.
- Dental Implants: For replacing missing teeth with implants that better replicate the function and feel of natural teeth.
- Orthopedic Implants: Potential use in bone implants where enhanced integration and sensory feedback are beneficial.
- Cranio-Maxillofacial Implants: Useful in reconstructive surgeries requiring implants that integrate well and restore function.
Geography of IP
Type of IP
201721017183
507009