Smartsense: Platform for ‘critical’ healthcare in India
A delivery of an affordable point-of-care critical care analyser completely tested on physiological controls and physiological and pathological samples which will be able to sense sodium, potassium, bicarbonate, glucose and urea, within a Turn-Around-Time (TAT) of 15-20 minutes. Our solution would impact hugely on patient’s disease management by reducing TAT and thus reducing the need for repeated tests. India’s headcount is 17.5% of world population and shares 20% of the global disease burden. 28% of population (urban) receives 66% of Healthcare.
Development of a low-cost water monitoring kit for multiplex heavy metal detection based on aptamer sensors
With the growth of human population, industrialisation and urbanisation, the demand for safe drinking water continues to increase, and along with it, the problem of water pollution
has become a concern. It is estimated that contaminated water causes 30,000 deaths aroundthe world every day. Among the toxic contaminants released to our drinking water are non-
PCLGCIR820 composite nanoparticles as theranostic agents for cancer therapy
Recently, photothermal therapy (PTT) has attracted tremendous attention because of its high efficacy in tumor ablation and minimal damage to normal tissues. A variety of organic photothermal agents have also emerged in recent years, aiming at replacing their inorganic counterparts, which usually are not biodegradable Among various cyanine derivatives, ICG is one of the most commonly employed medical imaging dyes and approved by US Food and Drug Administration (FDA) for clinical use on patients, which has been widely investigated for photothermal cancer therapy.
Drug delivery device for management of chemotherapy induced nausea and vomiting
Emesis in general is natural defensive mechanism of the body to prevent the absorption of the noxious substances in the Gastro Intestinal tract by forceful expulsion of contents. National Cancer Institute at National Institute of Health explains the phenomenon, ‘Nausea is a subjective phenomenon of an unpleasant, wavelike sensation experienced in the back of the throat and/ or the epigastrium that may culminate in vomiting (emesis). Vomiting is the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity.
A novel point-of-care detection device using nanotechnology for diagnosing periprosthetic infection following orthopedic surgery
Periprosthetic infection becomes a dilemma when the signs and symptoms that commonly coincide are absent, or when infection occurs in the immediate post-operative period when the usual biologic markers such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are still elevated from the surgical procedure. The use of interleukins has become
Development of nanoengineered dual release graft for pain /inflammation management in osteoarthritis
Osteoarthritis (OA) is a chronic degenerative disorder of joints, which has multi- factorial etiology. OA is the second most common rheumatological problem and is most frequent joint disease with prevalence of 22-39% in India. Injectable polymeric composite gel are synthesised with tailor-made polymeric nanoparticles to achieve both controlled release and thermo-responsive on application of a heat pad on the desired site. The main objective of the project is to develop an intra- articular drug delivery system for OA using a composite in situ gelling system.
Low-cost indigenously developed bioresorbable bone screw for bone and soft-tissue fixation applications
Our research work focuses on indigenous development of low-cost bioresorbable medical bone screw for bone-soft tissue Fixation applications. There is a huge demand for orthopedic devices in India and worldwide. It is estimated that more than 100 million screws are used for bone or soft-tissue fixations per year globally.
To demonstrate proof-of-concept of bioresorbable bone screw prototype composed of novel composite biomaterial with advanced functionality:
Design and development of point-of-care test kit for early diagnosis of chronic kidney disease
The risk of chronic kidney disorder, preeclampsia and other diseases which affect the albumin and creatinine level can be detected at an earlier stage by estimating the albumin and creatinine ratio. According to many reports including WHO 2014, 8-10% of the world population is affected by kidney related diseases. In India, there are more than 10 million cases every year for chronic kidney disease (CKD). Preeclampsia is another life-threatening disorder that occurs during pregnancy (affecting 1 in 20 pregnancies), childbirth and postpartum period.It causes high blood pressure and a
Proteomics for translational research:Focus on brain tumors and infectious diseases
Proteomics is the study of entire protein complement in a cell at a given time. It is a rapidly growing field, and is set to become an integral part of translational research. The implementation of proteomics in clinical research can lead to novel developments in the field of personalised medicine, biomarker discovery. This also provides mechanistic insights about disease occurrence and pathogenesis.
Sensors for all
The Biosensors and Bioinstrumentation (BSBI, pronounced busybee) lab works on the development of sensors and instrumentation systems for widescale deployment. The sensors are mostly optical fiber based, although electrochemical sensors also form a part of the lab activities. These sensors and sensing platforms can be adapted to detect a wide variety of chemicals, be they biological or non-biological in origin.