The invention provides a novel nail enamel composition with photoactivated antibacterial and antifungal properties to treat onychomycosis. The composition includes Rose Bengal dye as a photosensitizer, which generates reactive oxygen species (ROS) when exposed to light, killing microbes. The enamel also contains polymers like cellulose acetate and PMMA to form a durable, water-resistant film, and lactic acid to enhance penetration. This formulation offers a convenient and effective way to treat nail infections with prolonged antimicrobial action.
Figure (1) (A) growth of E coli in formulation containing rose bengal dye, (B) growth of E coli in only rose bengal dye, and (C) control containing no rose Bengal dye
- Onychomycosis affects up to 19% of the world’s population, causing significant discomfort and complications.
- Current treatments face challenges with microbial resistance, limited efficacy, side effects, and difficulty in drug delivery through the nail's keratin structure.
Traditional topical treatments are easily removed and have poor penetration, reducing effectiveness.
There is a need for a cost-effective, non-toxic, water-resistant nail enamel with extended antimicrobial action for a more effective and convenient treatment of onychomycosis.
- Broad-spectrum antibacterial and antifungal activity exhibited, effective against onychomycosis.
- Prolonged protection provided by a durable, water-resistant layer over the nails, giving a one-stop solution to microbial killing.
- Cost-effective, using affordable antibacterial agents without compromising efficacy.
The efficacy of the solution has been tested in laboratory conditions using bacterial and fungal plates. The nail enamel composition demonstrated no bacterial growth on plates with E. coli and S. aureus. It also more effectively inhibited the growth of C. albicans compared to just RB dye.
The nail enamel composition demonstrated no bacterial growth on plates with E. coli and S. aureus. It also more effectively inhibited the growth of C. albicans compared to just RB dye.
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- Enhanced Public Health: The nail enamel provides an effective treatment for onychomycosis, improving nail health and reducing complications from infections, thus enhancing overall public health.
- Combating Antimicrobial Resistance: Utilizing photoactivated Rose Bengal dye offers a novel treatment mechanism, reducing the risk of developing resistant microbial strains and providing an alternative to traditional antibiotics.
- Cost-effective and Accessible: The formulation is affordable and easy to use, making it accessible to a broader population and potentially reducing healthcare costs associated with treating nail infections.
Medical and Healthcare, to provide a more effective treatment for Onychomycosis.
Geography of IP
Type of IP
202221043596
533566