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Industrial Research And Consultancy Centre
Patent
Alloy, Bi and Tri Metallic Nanoparticles and Method for Green Synthesis of Said Nanoparticles
Abstract

The invention offers a green, biocompatible method for synthesizing mono-, bi-, tri-metallic, and alloy nanoparticles using Borassus flabellifer fruit extract. These nanoparticles are effective in biomedical applications including photothermal therapy.

Figure (1A) Showing colour changes: (i) reddish brown for 1mM silver NPs, (ii) yellowish brown for 1 mM Ag-Pd bimetallic NPs and (iii) deep purple colour for 1 mM synthesized Au-Pd bimetallic NPs.; (1B) Showing colour changes: (i) for gold nanoparticles (ii) for Palladium nanoparticles; (1C) Showing colour changes: (i) Reddish brown silver monometallic NPs, (ii) Showing colour changes to greyish for 1 mM Ag-Pt bimetallic NPs and (iii) Purple colour for 1 mM synthesized Ag-Pt-Au trimetallic NPs, (iv) Bluish purple colour for 1mM synthesized Ag-Pt/Au alloy NPs; (1D) showing colour changes: (a) for platinum nanoparticles

Problem Statement

Traditional nanoparticle synthesis involves toxic chemicals and harsh conditions, limiting their biocompatibility and scalability. An eco-friendly, biologically safe synthesis method is needed for advanced applications.

Uniqueness of the Solution
  • Green Chemistry Base: The technology uses a plant-based, sunlight-assisted synthesis method that eliminates the need for harsh chemicals and energy-intensive procedures, making the process environmentally friendly and sustainable. 
  • Core-Shell and Alloy Formation: It enables the formation of both core-shell and alloy nanoparticle structures with controllable morphology and optical properties, offering flexibility for diverse functional applications. 
  • Photothermal Efficiency: The synthesized nanoparticles can efficiently convert near-infrared (NIR) light into heat, reaching temperatures above 50°C, which is sufficient for effective tumor cell ablation in photothermal therapy. 
  • Confirmed Biocompatibility: In vitro studies demonstrate that Au-Pd nanoparticles exhibit high biocompatibility, showing minimal cytotoxicity when tested on human fibroblast cell lines. 
  • Scalable & Cost-effective: The process is simple and economical, utilizing naturally available and low-cost plant materials, making it suitable for large-scale production and commercial deployment.
Prototype Details

Nanoparticles synthesized via sunlight-assisted reaction between metal salts and Borassus flabellifer extract. It has been characterized using UV-Vis, TEM, SAED, EDS. It has been tested for cytotoxicity and photothermal response in vitro.

Current Status of Technology

This technology is developed at laboratory scale and tested for cancer therapy and imaging.

Technology readiness level

2

Societal Impact

This green synthesis process offers a sustainable, cost-effective, and non-toxic alternative for nanoparticle production. It paves the way for safer medical treatments, especially in cancer phototherapy, while minimizing environmental hazards.

Applications or Domain
  • Medical Diagnostics & Therapy: Non-invasive cancer treatment via photothermal agents 
  • Catalysis: Multi-metallic nanocatalysts for industrial reactions 
  • Environmental Science: Biocompatible nanomaterials for pollutant remediation 
  • Nanotechnology & Materials Science: Alloy NPs for advanced functional materials 
  • Pharmaceuticals: Drug delivery and diagnostic imaging aids

Geography of IP

Type of IP

Application Number

201721029703

Filing Date
Grant Number

541022

Grant Date
Assignee(s)
Indian Institute of Technology Bombay
**This IP is owned by IIT Bombay**