The invention offers a green, biocompatible method for synthesizing mono-, bi-, tri-metallic, and alloy nanoparticles using Borassus flabellifer fruit extract. These nanoparticles are effective in biomedical applications including photothermal therapy.
Figure (1A) Showing colour changes: (i) reddish brown for 1mM silver NPs, (ii) yellowish brown for 1 mM Ag-Pd bimetallic NPs and (iii) deep purple colour for 1 mM synthesized Au-Pd bimetallic NPs.; (1B) Showing colour changes: (i) for gold nanoparticles (ii) for Palladium nanoparticles; (1C) Showing colour changes: (i) Reddish brown silver monometallic NPs, (ii) Showing colour changes to greyish for 1 mM Ag-Pt bimetallic NPs and (iii) Purple colour for 1 mM synthesized Ag-Pt-Au trimetallic NPs, (iv) Bluish purple colour for 1mM synthesized Ag-Pt/Au alloy NPs; (1D) showing colour changes: (a) for platinum nanoparticles
Traditional nanoparticle synthesis involves toxic chemicals and harsh conditions, limiting their biocompatibility and scalability. An eco-friendly, biologically safe synthesis method is needed for advanced applications.
- Green Chemistry Base: The technology uses a plant-based, sunlight-assisted synthesis method that eliminates the need for harsh chemicals and energy-intensive procedures, making the process environmentally friendly and sustainable.
- Core-Shell and Alloy Formation: It enables the formation of both core-shell and alloy nanoparticle structures with controllable morphology and optical properties, offering flexibility for diverse functional applications.
- Photothermal Efficiency: The synthesized nanoparticles can efficiently convert near-infrared (NIR) light into heat, reaching temperatures above 50°C, which is sufficient for effective tumor cell ablation in photothermal therapy.
- Confirmed Biocompatibility: In vitro studies demonstrate that Au-Pd nanoparticles exhibit high biocompatibility, showing minimal cytotoxicity when tested on human fibroblast cell lines.
- Scalable & Cost-effective: The process is simple and economical, utilizing naturally available and low-cost plant materials, making it suitable for large-scale production and commercial deployment.
Nanoparticles synthesized via sunlight-assisted reaction between metal salts and Borassus flabellifer extract. It has been characterized using UV-Vis, TEM, SAED, EDS. It has been tested for cytotoxicity and photothermal response in vitro.
This technology is developed at laboratory scale and tested for cancer therapy and imaging.
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This green synthesis process offers a sustainable, cost-effective, and non-toxic alternative for nanoparticle production. It paves the way for safer medical treatments, especially in cancer phototherapy, while minimizing environmental hazards.
- Medical Diagnostics & Therapy: Non-invasive cancer treatment via photothermal agents
- Catalysis: Multi-metallic nanocatalysts for industrial reactions
- Environmental Science: Biocompatible nanomaterials for pollutant remediation
- Nanotechnology & Materials Science: Alloy NPs for advanced functional materials
- Pharmaceuticals: Drug delivery and diagnostic imaging aids
Geography of IP
Type of IP
201721029703
541022