Copper nanoparticle based disinfectant compositions, method of preparation and uses thereof. The present invention discloses copper nanoparticle based disinfectant composition having antimicrobial and antiviral properties. The disclosed disinfectant composition comprises copper nanoparticles, antioxidant oil, and straight chain hydrocarbon spacer. Further, a method for preparing the disclosed disinfection composition is also disclosed. The disclosed disinfectant composition includes stabilized copper particles in oil phase having a wide range of applications as coating or films on solid surfaces such as textiles, face masks, walls, personal care equipment, etc. and also may be incorporated into apparel, fabric, packaging material, personal care objects, healthcare objects, paints, paint thinners etc.
Figure 1(a) and 1(b) are images showing copper nanoparticles (CuNP) stabilized with rosemary oil; wherein 5(a) shows stabilized nanoparticles after 5 minutes, and 5(b) shows stabilized nanoparticles after 60 minutes; (2) Is a graphical representation of results of microdroplet study of bacteriophage MS2, illustrating sustained disinfection pattern by copper nanoparticle in rosemary oil on cotton woven fabric; (3) Is bar graph representing percentage of disinfection (%) after 30 minutes versus number of washes.
Traditional disinfectants often contain harsh chemicals, posing health risks and environmental harm. These chemicals can irritate the skin, cause breathing issues, and even lead to bacteria becoming resistant to treatment. Moreover, many disinfectants lose their effectiveness quickly, needing constant reapplication. Existing surface disinfection methods struggle to effectively tackle evolving threats from viruses and bacteria. They aren't always strong enough, break down too fast, and raise environmental worries, meaning we have to use them a lot in places like hospitals and public spaces.
- Disinfectant Composition with Copper Nanoparticles: The invention features a disinfectant composition that includes copper nanoparticles stabilized by antioxidant oils derived from plants, such as rosemary oil, cinnamon oil, and clove oil, combined with at least one organic solvent base and a spacer made of a straight chain hydrocarbon.
- Nanoparticle Size and Concentration: The copper nanoparticles within the composition have a particle size ranging from 0.5 nm to 100 nm, and their concentration varies between 0.1 millimolar (mM) and 10 mM.
- Antioxidant Oil Stabilizers: The composition employs antioxidant oils as stabilizers, which are selected from rosemary oil, cinnamon oil, and clove oil, with a concentration range of 0.1 to 2 mM.
- Spacer and Organic Solvent Base: The spacer components can include stearic acid, lauric acid, oleic acid, dodecane thiol, and mercaptoundecanoic acid, with a concentration range of 0.01 to 10 mM. The organic solvent base options are toluene, acetone, xylene, and chloroform.
- Optional Additives and Agents: The composition may also contain additional components such as phase transfer agents (e.g., quaternary ammonium salts) in concentrations of 1 to 100 mM and reducing agents (e.g., sodium borohydride, hydrazine hydrate) in concentrations of 1 to 75 mM.
Five different formulations of copper nanoparticles were synthesized using various antioxidant oils as stabilizers and different spacers and characterized. Their antiviral efficacies were evaluated using model viruses and bacteria followed by testing with pathogens. These were immobilized on cloth surfaces, their leaching profiles and antiviral properties have been characterized. The cytotoxicity analysis of the modified cloth is being conducted. The nanoparticles can also be suitably integrated with polyurethane for use with masks, ppe and other surface coatings. Nanoparticles were synthesized using a source of metal ion, a stabilizer (oil), a molecule for steric hindrance, phase transfer agent and a reducing agent. Copper suphate, copper chloride or copper nitrate may be utilized as a precursor for copper. In our case, we used copper sulphate in molar fractions from 0.5 mM to 5 mM.
The technology has been validated through laboratory-scale studies demonstrating strong antiviral and antimicrobial efficacy on various substrates such as fabrics, plastics, and metals. Effectiveness has been confirmed using plaque assays and microdroplet disinfection studies against bacteriophage MS2, SUSP2, Staphylococcus aureus, and Pseudomonas aeruginosa. Based on this, the technology is currently at TRL 4 – laboratory demonstration and hypothesis testing.
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The invention contributes to improved public health by reducing the spread of infectious diseases and enhancing food safety standards. It also supports environmental sustainability through the use of biodegradable ingredients, minimizing ecological impact. Additionally, it plays a role in mitigating antimicrobial resistance, promoting safer and more effective longterm health outcomes.
- Healthcare: Hospitals, clinics, diagnostic centers, PPE and medical textiles.
- Food and Beverage: Packaging surfaces, processing equipment, hygiene stations.
- Public Spaces: Airports, stations, malls, religious places, schools.
- Transportation: Buses, trains, airlines, shared mobility services.
- Consumer Products: Surface disinfectants, sprays, household coatings.
- Textile Industry: Antiviral and antimicrobial fabrics and garments.
- Coating & Paints: Antimicrobial paints, wall and surface coatings.
- Packaging Industry: Antimicrobial layers in food and pharma packaging.
- Facility Management: Sanitation solutions for residential and commercial complexes.
- Industrial Hygiene: Cleanroom and contamination-sensitive environments.
Geography of IP
Type of IP
202021047319
505699