This patent describes a method for producing microneedle array master templates and negative molds using a photopolymerization-based three-dimensional printing method. The process is designed to be fast, cost-effective, and simple, overcoming many limitations of current fabrication techniques. The resulting microneedle array master templates are highly robust, long-lasting, and reusable, providing a reliable foundation for producing microneedle arrays. The invention also details a method for creating negative molds from these master templates, facilitating the mass production of microneedles with high precision and superior mechanical properties.
Figure (1) Microneedle master mold
Transdermal drug delivery systems (TDDS) are a promising alternative to traditional drug delivery methods due to their minimally invasive nature. However, the efficacy of TDDS is limited by the skin's barrier properties, particularly the stratum corneum, which restricts drug penetration. Microneedle (MN) technology offers a solution by creating microscopic channels in the skin to enhance drug delivery. However, the fabrication of high-quality MN master templates is hindered by existing methods that are expensive, time-consuming, and require sophisticated equipment and skilled personnel. These methods often involve multiple post-processing steps with hazardous chemicals which complicates the process and limits scalability.
- The method is fast and cost-effective for producing microneedle array master templates.
- The master templates are robust, long-lasting, reusable, scalable and durable.
- The process eliminates the need for extensive post-processing and the use of hazardous chemicals which makes it safer.
- The approach improves precision and geometric control of the microneedle structures, ensuring high resolution and reproducibility.
- It simplifies the fabrication process by using photopolymerization-based three-dimensional printing, which does not require sophisticated equipment or skilled personnel.
Prototypes of microneedle (MN) array master templates fabricated using the disclosed method. These prototypes include 5x3 and 7x7 MN arrays. Further, the patent compares these annealed, spin-coated prototypes with conventionally produced, unannealed master templates, highlighting their improved strength and precision. The final output also includes PDMS negative molds replicated from these enhanced master templates, showcasing their effectiveness in producing high-quality microneedle molds without the typical adherence issues.
Microneedle master templates have been created using this process. The technology is ready to be deployed.
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This technology can significantly enhance patient compliance in drug delivery by providing a painless and minimally invasive alternative to traditional injection methods. It can reduce healthcare costs and improve the efficiency of drug delivery systems, making advanced therapies more accessible.
Pharmaceutical, Biomedical, Healthcare, Materials and Manufacturing, Nanomedicine, Biotechnology.
Geography of IP
Type of IP
202221036495
434130