The invention presents a nano-engineered biodegradable polymer- composite specifically designed for bone-soft tissue fixation. This advanced composite integrates biodegradable polymers with bioactive nano-fillers like Magnesium Oxide (MgO) and silk fibroin, aiming to enhance orthopedic device functionality such as screws and plates.
Traditional metallic bone fixation implants and non-degradable polymer-based devices present challenges including stress shielding, secondary surgical removal, inflammatory response, and poor integration with surrounding tissues. There is a clear need for a biocompatible, biodegradable composite for bone-soft tissue fixation that can provide sufficient initial mechanical strength while gradually degrading to enable natural tissue regeneration, minimizing long-term complications and eliminating the need for a second surgery.
- Silk Fibroin Incorporation: Provides superior biocompatibility and supports cell adhesion, aiding soft tissue integration.
- Bioactive MgO Nanoparticles: Reinforces mechanical properties while stimulating bone regeneration and osteoconductivity.
- Fully Biodegradable Composite: Eliminates need for secondary surgery by naturally resorbing in the body after healing.
- Hybrid Matrix Structure: Combines polymer, protein, and ceramic elements for synergistic mechanical strength and gradual, predictable degradation.
The prototype consists of a biodegradable composite manufactured by combining polycaprolactone (PCL), silk fibroin, and magnesium oxide nanoparticles using solvent casting and particulate leaching techniques. Prototype test samples were produced in the form of screws and plates, evaluated for tensile and compressive strength, as well as in vitro degradation and cytocompatibility with osteoblast cell lines. These results confirm that the composite has promising features for orthopedic and soft tissue fixation applications.
A lab-scale prototype of the composite has been successfully developed and tested for its mechanical strength, biodegradability, and cytocompatibility. In vitro evaluations have demonstrated improved biocompatibility and controlled degradation over conventional materials, with enhanced mechanical stability suited for bone-soft tissue repair. The technology is currently at a late preclinical research stage and is available for licensing.
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This technology can significantly improve orthopedic and reconstructive surgical outcomes by offering patients a safe, biocompatible, and resorbable alternative to metallic implants. It reduces the need for secondary removal surgeries, limits inflammatory complications, and supports faster, more natural healing. Ultimately, this composite material can contribute to cost-effective, patient-friendly orthopedic treatments, improving quality of life and reducing healthcare burdens.
- Orthopedic Surgery: Used for fixation of fractures and joint reconstruction with gradual resorption.
- Pediatric Orthopedics: Provides safe and biocompatible fixation materials for children, reducing revision surgeries.
- Sports Medicine: Assists in repairing ligament and tendon attachments with improved tissue integration.
- Reconstructive Surgery: Ideal for soft tissue-to-bone healing in complex reconstructive procedures.
Geography of IP
Type of IP
201611012973
452521