The present invention relates to the development of nanocomposite of fluorescent gold nanoclusters conjugated crumpled MXene nanosheets. Particularly, it relates to the nanocomposite of red emissive gold nanoclusters and crumpled MXene nanosheets for applications of bioimaging, photothermal therapy and sensor.
Figure (1) Transmission electron microscopy image of (a) Gold nanocluster (b) Crumpled MXene (MX) (c-d) MX_Au NCs
There is a need for a scalable and biocompatible nanocomposite that can simultaneously enhance bioimaging and photothermal therapy. Existing materials lack the combined properties necessary for efficient production and multifunctional biomedical applications. The invention solves this by developing a nanocomposite of red emissive gold nanoclusters conjugated with crumpled MXene nanosheets, offering improved efficacy and versatility in bioimaging, photothermal therapy, and sensor applications.
- The preparation method involves dispersing crumpled MXene, adding a conjugating agent, incorporating gold nanoclusters, and processing via centrifugation, dialysis, and freeze-drying.
- The nanocomposite is designed for use in bioimaging, photothermal therapy, and sensor applications, optionally conjugated with a photosensitizer like folic acid.
- Combines red-emissive gold nanoclusters with crumpled titanium carbide (Ti3C2) MXene nanosheets, creating a nanocomposite with enhanced photothermal and bioimaging properties.
- This substance can be used to both see and treat cancer cells in the body.
- It's easy to produce in large amounts and is safe for use in medical applications.
- The unique combination of materials makes it more effective than current options for imaging and therapy.
A lab-scale prototype has been developed comprising red-emissive gold nanoclusters (2–10 nm) conjugated onto crumpled MXene (Ti3C2) nanosheets (300–400 nm) through a controlled synthesis process involving dispersion, conjugation, centrifugation, dialysis, and freeze-drying. The prototype demonstrates enhanced fluorescence for bioimaging and efficient photothermal conversion for targeted cancer therapy.
- Method Established: The method for synthesizing the nanocomposite has been successfully developed and tested.
- Nanocomposite Characteristics: The nanocomposite features fluorescent gold nanoclusters (2-10 nm) on crumpled MXene nanosheets (300-400 nm).
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- Improved Cancer Treatment: Enhances the precision and effectiveness of cancer therapies, potentially leading to better patient outcomes and fewer side effects.
- Enhanced Medical Diagnostics: Advances in bioimaging capabilities can lead to earlier and more accurate detection of diseases.
- Bioimaging: The nanocomposite's fluorescent properties enhance the visualization of biological tissues and cells, aiding in precise medical imaging.
- Photothermal Therapy: The nanocomposite converts light into heat, making it effective for targeted cancer treatments by destroying cancer cells with minimal damage to surrounding tissues.
- Sensors: The unique combination of materials allows the nanocomposite to be used in sensitive detection devices for monitoring biological and environmental changes.
Geography of IP
Type of IP
202221001796
404681m