Metal nanoparticles, especially gold nanoparticles, are valuable for biomedical applications like cancer therapy due to their unique optical properties. However, traditional synthesis methods involve toxic surfactants like CTAB, limiting their biocompatibility. This invention addresses this by providing a method for synthesizing biocompatible gold nanoparticles without CTAB, using Dodecyl Ethyl Dimethyl Ammonium bromide (DMAB) instead.
Figure (1) are FEG-TEM images of solution showing the nanoparticles synthesized according to embodiments herein; (2) FEG-TEM images of solution showing the NBPs synthesized according to embodiments herein;
Metal nanoparticles, especially gold nanoparticles, are valuable for biomedical applications like cancer therapy due to their unique optical properties. However, traditional synthesis methods involve toxic surfactants like CTAB, limiting their biocompatibility. This invention addresses this by providing a method for synthesizing biocompatible gold nanoparticles without CTAB, using Dodecyl Ethyl Dimethyl Ammonium bromide (DMAB) instead.
The use of DMAB as a non-toxic surfactant in the synthesis process ensures high biocompatibility of the nanoparticles, making them suitable for biomedical applications. This method results in nanoparticles with high monodispersity and uniform size and morphology, which is crucial for consistent biomedical performance.
Salient technical feature(s):
- Use of DMAB instead of CTAB for biocompatibility.
- Seed-mediated growth method for controlled nanoparticle synthesis.
- High reproducibility and scalability of the synthesis method.
- Production of nanoparticles with uniform size and morphology.
- Ability to produce gold nanobipyramids and other shapes with high dispersity.
Advantages of the technology:
- Enhanced biocompatibility of nanoparticles.
- Reduced toxicity due to the absence of CTAB.
- High reproducibility and scalability in nanoparticle production.
- Improved suitability for biomedical applications like photothermal therapy and contrast imaging.
- Uniform and well-defined nanoparticle shapes.
The prototype involves the synthesis of gold nanoparticles using a seed-mediated growth method with DMAB as a surfactant. The process includes preparation of gold seed solutions, growth solutions, and incubation to form nanoparticles. The resulting nanoparticles are characterized by high monodispersity and biocompatibility, making them suitable for various biomedical applications.
The technology is in the basic research and protocol development stage.
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This invention can significantly impact cancer treatment by providing more effective and biocompatible nanoparticles for photothermal therapy. It can also improve diagnostic imaging techniques, leading to earlier and more accurate disease detection. The reduction in toxicity associated with nanoparticle synthesis benefits both patient safety and environmental sustainability.
- Theranostics: Combines therapy and diagnostics using gold nanoparticles to both detect and treat diseases like cancer, enabling personalized and targeted treatment.
- Bio-imaging: Gold nanoparticles enhance imaging contrast in techniques like CT or optical imaging, allowing clearer visualization of tissues and tumors.
- Nanomedicine: Utilizes gold nanoparticles for targeted drug delivery, ensuring that therapeutic agents reach specific cells or tissues with minimal side effects.
- Phototherapy: Gold nanoparticles convert light into heat for photothermal therapy , selectively destroying cancer cells without harming surrounding healthy tissue.
Geography of IP
Type of IP
202021037002
438420