The invention involves an orally administrable pharmaceutical preparation that encapsulates proteins, specifically insulin, using metal oxide nanoparticles and amino acids. This formulation allows proteins to be effectively absorbed in the gastrointestinal tract without being degraded by stomach acids and enzymes.
Figure (1) Orally Administrable Pharmaceutical Preparation
Managing diseases like diabetes traditionally requires frequent insulin injections, which can be cumbersome and painful. Additionally, insulin is typically degraded by the gastrointestinal environment, making oral administration challenging due to poor bioavailability.
- Nano-Encapsulation and Amino Acid Adduct: Uses metal oxide nanoparticles and amino acids to protect proteins like insulin, enhancing stability and gastrointestinal survivability.
- Oral Delivery: Facilitates oral administration of proteins, potentially replacing injections and improving patient compliance.
- Controlled Release: Ensures proteins are released at optimal rates in the intestines, maximizing therapeutic effectiveness.
- Enhanced Bioavailability: Overcomes challenges of protein degradation in the stomach, significantly improving bioavailability for oral dosing.
The prototype encapsulates insulin with metal oxide nanoparticles, ensuring its stability and enhancing bioavailability for oral intake. It effectively shields insulin from stomach acids and improves absorption in the intestines. Testing in lab settings has confirmed its functionality and potential for clinical use, marking a significant development towards easier diabetes management.
- The current technology has been successfully tested in prototype form, demonstrating its ability to protect insulin from gastrointestinal degradation and enhance its bioavailability when administered orally.
- These tests have validated the effectiveness of the nano-encapsulation and controlled release mechanisms, showing promising potential for replacing injections in diabetes management.
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This invention has the potential to significantly impact public health by providing a less invasive and more patient-friendly approach to managing diabetes. It could improve quality of life for millions of patients by reducing the need for daily injections and enhancing treatment adherence.
Pharmaceuticals, Healthcare and Diagnostics, Biotechnology
- Pharmaceutical Manufacturing: Used in creating oral insulin and other protein- based medications.
- Diabetes Care: Enhances patient compliance and comfort in managing diabetes through oral treatments.
- Public Health: Offers accessible diabetes treatment options in resource-limited settings.
- Research and Development: Supports innovation in protein therapy delivery methods in clinical research environments.
201621005792
410544