This invention is designed for the efficient capture and analysis of very small biological entities such as single cells and microorganisms. It uses magnetic droplets to manipulate and study these particles in a detailed and precise manner without the need for electrical power.
Figure (1) Shows three layers: Top plate containing microwells, bottom plate containing micropillars, and spacers in between for movement of the magnetic liquid marble; (2a) An opening of shell around the marble to allow capturing of biological entities in the microwells; (2b) Representation of captured biological entities in microwells
Often, biological studies need to handle small amounts of liquids, which is tricky and typically requires expensive equipment. This device simplifies the process by using a magnet to move liquid droplets that contain the samples into tiny wells on a surface. Traditional methods require extensive resources, including significant amounts of chemicals and complex equipment, and often necessitate skilled personnel to operate. These methods are costly, time-consuming, and not suitable for use outside of well-equipped labs.
- Power-free operation: The device operates entirely without electricity. Hence, it is ideal for field use or in areas without reliable power due to the inclusion of:
- Two-component system that includes a top plate with microwells for capturing samples and a bottom plate with micropillars to guide and position the samples;
- Magnetic liquid marbles that utilize droplets mixed with magnetic particles to transport biological samples into the microwells; and
- Manual magnetic manipulation that allows precise control over sample placement using a simple handheld magnet, eliminating the need for electrical power or complex machinery.
- Cost-effective and simple: It lowers both production and operational costs, making it accessible to a wide range of users.
- High precision and reduced sample loss: It ensures that samples are handled gently and precisely, improving the accuracy and efficiency of the analysis.
The prototype includes specific dimensions and materials for both plates, showing successful application in capturing a range of biological samples. These prototypes demonstrate the device’s functionality and its adaptability for different scientific needs.
The prototype has been developed and successfully tested, demonstrating the device’s functionality and adaptability for different scientific needs.
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The device improves access to diagnostics in under-resourced areas through affordable and easy-to-use tools. It reduces healthcare costs by minimizing the need for expensive lab equipment and training.
- Health diagnostics: Particularly useful in remote or resource-limited settings for quick disease detection
- Biological research: Supports advanced scientific investigations of cells and biomolecules
- Environmental monitoring: Suitable for on-site testing of environmental samples like water and soil for contaminants
- Food safety and quality control
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