This invention relates to a nano-complex comprising (i) nanospheres with a first drug entrapped within said nanospheres and (ii) lipid based nanocochleates with a second drug encapsulated therein, characterized in that, said nanospheres are chemically or physically linked either within or on the surface of the nanocochleate such that a combination of drugs are co-encapsulated in a single nanosphere-nanocochleate complex.