Anticancer activity of α -functionalised nitroalkenes
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α -Functionalised nitroalkenes
■ Small multi-functional molecules with high potential in synthesis and biology
■ Synthesised through one-pot, multi-component reactions at room temperature
■ Inhibit HeLa cell proliferation by binding to tubulins and depolymerising microtubules at low micromolar concentrations
■ Bind to tubulin at a site distinct from the vinblastine and colchicine binding sites and induce conformational changes in the tubulin
■ Promising lead compounds for cancer therapy
Prof. I N Namboothiri