Cryo EM is an advanced imaging technique used to elucidate the three-dimensional (3D) structure of biological molecules and complexes at near-atomic resolution. In this technique, the sample is rapidly frozen to temperatures below -150 °C, trapping it in vitreous ice.

Cryo EM is an advanced imaging technique used to elucidate the three-dimensional (3D) structure of biological molecules and complexes at near-atomic resolution. In this technique, the sample is rapidly frozen to temperatures below -150 °C, trapping it in vitreous ice.

Prior to securing a slot for the Krios 300kV microscope, users must first examine the sample on a negatively stained grid, followed by screening on a cryo-conditioned grid using the Talos 120kV microscope. This data should be submitted at the time of slot booking.

• Online registration is required for users.
• Pre-registration is mandatory for external users.
• Appointments will be scheduled based on the queue and communicated via email.
• New users are advised to reach out to the CryoEM lab prior to registration.
• Users must provide at least 24 hour’s notice to the CryoEM lab if they wish to cancel or postpone their slot.

Internal users are required to register online, while external users are also instructed to register online. Appointments will be allocated based on the queue and communicated via email. New users are encouraged to reach out to the CryoEM lab before initiating the registration process.