A novel nanoemulsion-based transdermal patch system for efficient and stable drug delivery has been developed. It enables ethanol-free delivery of both hydrophobic and hydrophilic drugs with high bioavailability and minimal irritation.
Figure (1) TEM image of amoxicillin loaded corn oil nanoemulsion; (2) TEM image of mustard oil nanoemulsion
Conventional transdermal drug delivery systems and nanoemulsions often rely on harmful organic solvents like ethanol, face challenges of low drug loading, instability, and complexity in processing. There is a need for a safer, effective, and stable drug delivery platform that enables both hydrophilic and hydrophobic drug administration through the skin.
- Ethanol-Free Formulation: It eliminates the use of ethanol, reducing skin irritation and toxicity risks, especially in pediatric and geriatric use.
- Biocompatible Components: This technology uses edible oils (e.g., corn oil) and non-ionic surfactants, ensuring safety and enhanced patient compliance.
- Dual-Phase Drug Loading: It is capable of encapsulating both hydrophilic and hydrophobic drugs due to oil and aqueous phases.
- Green & Scalable Process: Its solvent-free preparation with minimal energy input; no trained personnel required.
- High Stability and Permeability: It is thermodynamically stable nanoemulsion with <200 nm droplet size; no phase separation even after 6 months at 4°C.
The nanoemulsion is made using corn oil, Tween 80, and Span 60, and loaded onto a polyester patch with polyacrylate adhesive. It has been validated through SEM, TEM, Franz diffusion studies, in vivo pharmacokinetics, and ASTM standard patch tests.
The technology is currently in the pre-clinical research phase, where proof-of-concept studies have been successfully conducted.
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This patch platform enables painless, safe, and sustained drug delivery, particularly benefiting pediatric, geriatric, and remote patient care. Its biodegradable nature and solvent-free formulation also reduce environmental burden.
- Healthcare and Medical Devices: Provides a non-invasive, user-friendly patch for safe and effective drug delivery
- Pharmaceuticals and Drug Delivery: Enables stable, ethanol-free transdermal delivery for various drugs
- Pediatric and Geriatric Care: Ideal for children and elderly due to gentle application and sustained release
- Biotechnology and Biomedical Engineering: Supports biocompatible, green technologies for advanced therapeutic delivery
Geography of IP
Type of IP
201721044997
429404