The present invention relates to bimetallic composite platinum integrated gold nanorods and a process of preparation thereof. The synthesis method produces highly stable bimetallic nanorods which are easily reproducible and scalable. The synthesized nanorods demonstrate controlled morphology, uniformity and improved optical properties. The present invention also relates to the uses of platinum integrated gold nanorods in various applications of imaging, phototherapy, nanotheranostics, cancer nanomedicine and the like.
Figure (1 a,a1) Illuatrate X-ray radiocontrast; (1 b,b1) Photoacoustic Imaging ability of designed nanorods; (1 c) % cell viability analysis measure by MTT assay at various concentrations.
There is a long felt need to develop an efficient process for the preparation of gold-platinum bimetallic nanorods that is simple, fast, involves few steps, ambient procedure, easy purification, scalable and reproducible, and produces a gold-platinum bimetallic nanorod with appropriate aspect ratio, is stable, uniformly distributed and has a controlled morphology.
- Simple Design Using CTAB Surfactant: The synthesis employs a straightforward method using CTAB to form bimetallic plasmonic nanorods efficiently.
- Ambient Procedure and Easy Purification: The process operates under mild conditions and allows for easy post-synthesis purification of the nanorods.
- Tunable and Scalable with High Reproducibility: The synthesis method supports scaling up and allows precise control over composition and morphology for consistent results.
- Controlled Particle Size and Unique Plasmonic Properties: The nanorods exhibit narrow size distribution and tunable surface plasmon resonance, enhancing their optical performance.
- High Stability of Bimetallic Nanorods: The integrated platinum-gold structure ensures chemical and morphological stability over time.
- Enhanced Morphology, Uniformity, and Optical Properties: The nanorods produced are uniform in shape and size with superior optical characteristics, making them ideal for theranostic applications.
The present invention provides a process for the preparation of bimetallic platinum-integrated gold nanorods through a seed-mediated growth method. Initially, a seed solution containing gold nanoparticles is prepared by reducing chloroauric acid (HAuCl4) with sodium borohydride (NaBH4) in the presence of cetyltrimethylammonium bromide (CTAB). Separately, an aqueous growth solution is formulated comprising CTAB, HAuCl4, silver nitrate (AgNO3), potassium tetrachloroplatinate (K2PtCl4), and ascorbic acid in specific concentration ranges. The gold seed solution is then added to the growth solution, initiating the formation of bimetallic platinum-integrated gold nanorods. The concentration of CTAB is maintained between 0.1 M and 1 M, HAuCl4 between 5 mM and 20 mM, AgNO3 between 2 mM and 8 mM, K2PtCl4 between 2 mM and 20 mM (to control platinum thickness), and ascorbic acid between 50 mM and 100 mM. The resulting nanorods typically contain platinum and gold in a ratio of 5:100 to 20:100, with an average diameter of 8–15 nm, length of 20–50 nm, and an aspect ratio between 2 and 5. The particles exhibit tunable surface plasmon resonance (SPR) characteristics, making them suitable for various optical and biomedical applications
Technology has been developed at the laboratory scale and tested for in vitro level.
3
The invention offers a powerful platform for cancer diagnosis and treatment through a single nanomaterial, combining imaging and photothermal therapy. Its scalable, low-cost synthesis method makes advanced nanomedicine more accessible. By improving precision and reducing side effects in cancer therapy, it contributes to better patient outcomes and healthcare efficiency.
- Cancer diagnostics and nanomedicine
- Theranostics and personalized healthcare
- Biomedical imaging and contrast agents
- Photothermal therapy and oncology
- Nanomaterials and advanced drug delivery systems
- Biophotonics and optical sensing
- Medical device and diagnostic tool development
- Pharmaceutical and life sciences research
Geography of IP
Type of IP
202021032307
482224