This innovative technology for bio-implants is designed to enhance osseointegration—the process by which implants integrate with bone. The technology leverages a specialized biodegradable coating applied via an advanced electrospinning method, which accelerates bone growth around implants such as dental, orthopedic, and cranio-maxillofacial implants.
Figure (1) Schematic of a root-form coated dental implant, its surface morphology observed under scanning electron microscopy (SEM), and in vivo evaluation of osseointegration in a rabbit tibia model at different healing time points. The nanofiber-coated surface supports bone-implant integration, as demonstrated by gross specimen photographs and radiographs.
Traditional bio-implants, whether coated or uncoated, typically suffer from slow osseointegration, taking 3 to 4 months to fully integrate with bone tissue. This slow integration process can delay recovery and prolong discomfort for patients. There is a pressing need for bio-implants that can achieve faster osseointegration to expedite the healing process, particularly in critical applications such as dental, orthopedic, and cranio-maxillofacial implants.
- Biodegradable Osteogenic Nanofiber Coating: Includes Polycaprolactone, gelatine type A, dexamethasone, β-glycerophosphate, ascorbic acid, and hydroxyapatite, enhancing bone cell attraction and growth.
- Accelerated Osseointegration: The coating facilitates rapid differentiation of mesenchymal stem cells, speeding up bone regeneration and integration.
- Mimics ECM (Extracellular Matrix): The coating not only promotes healing but also mimics the natural bone environment, providing an ideal scaffold for bone growth.
The prototype for the advanced bio-implant technology features a specialized biodegradable coating composed of Polycaprolactone, gelatin type A, dexamethasone, β-glycerophosphate, ascorbic acid, and hydroxyapatite. This composition has been proven to significantly accelerate osseointegration, reducing the typical integration period from 3-4 months to substantially less, thereby enhancing the implant's mechanical properties and promoting faster healing.
The advanced bio-implant technology is currently at the prototype stage, with initial testing showing that its biodegradable coating significantly speeds up osseointegration, reducing typical recovery times. The technology is preparing for further clinical trials to validate its efficacy and safety, moving closer to potential clinical use.
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The development of these advanced bio-implants represents a significant advancement in medical technology, potentially reducing recovery times, improving surgical outcomes, and enhancing the quality of life for patients undergoing implant surgeries. This technology aligns with the ongoing need for more efficient and patient-friendly medical treatments, particularly in aging populations and in areas with high rates of trauma injuries.
- Dental Implants: For faster recovery in tooth replacement.
- Orthopaedic Implants: Critical in surgeries involving joints and bone reconstruction.
- Cranio-Maxillofacial Implants: Used in reconstructive surgeries of the facial and cranial bones.
Geography of IP
Type of IP
201721000148
495539