The invention presents an MXene composite nanosheet designed to overcome the limitations of traditional MXenes, such as poor durability and biocompatibility. The nanosheet is made by selectively etching A atoms from a MAX phase material (e.g., Ti £ AlC ¢ ) using an etching solution (e.g., hydrofluoric acid) and then conjugating it with a cationic polymer (e.g., polyethyleneimine). The method includes dispersing the MAX compound in the etching solution, centrifuging, drying, and hydrothermally treating the polymer-conjugated MXene. This results in a composite nanosheet with improved stability and functionality for applications in biomedical and environmental fields.
Figure (1) shows morphological characterization of PEI conjugated MXene nanosheets in accordance with an embodiment of the invention
- Inferior Durability: MXenes tend to degrade due to their high surface energy.
- Poor Biocompatibility limits their application in biomedical fields.
- High Tendency for Aggregation affects their performance in practical applications.
- Improper Reusability and Low Biodegrability reduces their cost-effectiveness and sustainability.
- Poor Dispersibility in Biological Media hinders their biomedical application.
- Cytotoxicity and Stability Issues require further research to ensure safety and efficacy.
Near-Infrared (NIR) Activity and Fluorescence : The PEI_MX nanosheets exhibit intrinsic NIR activity and fluorescence, making them suitable for applications in cell imaging and photothermal therapy.
- MXene nanosheets (MX) exhibit an average size of 585±144 nm and a thickness of 6.82±1.66 nm, indicating 2-3 layers. PEI_MX nanosheets have a smaller average size of 111.42±29 nm and a thickness of 2.63±0.85 nm, confirming successful size reduction and single-layer formation.
- PEI_MX nanosheets show no toxicity up to 200 μg/mL on mouse fibroblast cell line L929, indicating improved biocompatibility compared to MX nanosheets, which show reduced viability at 175 μg/mL.
Basic principles have been observed and reported.
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- Improved Diagnostics and Treatment due to enhanced biocompatibility and stability of MXene composite nanosheets make them ideal for developing advanced biomedical devices such as wearable sensors, photothermal therapy and cell labeling techniques.
- Efficient Wastewater Management is possible due to improved stability and dispersibility of MXene composite nanosheets. This can lead to more efficient removal of contaminants and pollutants from water sources, contributing to cleaner water and a healthier environment.
- Reduced environmental footprint due to development of biodegradable and less toxic MXene materials, promoting sustainability.
The enhanced stability, biocompatibility, and functional properties make the MXene composite nanosheets ideal for a wide range of applications, including environmental remediation and advanced biomedical devices.
Geography of IP
Type of IP
202121020879
484042