Patent
A scanless optical tomographic system
Abstract
This patent describes a scanless optical tomographic system, which simultaneously uses more than one optical line sources to perform a three-dimensional reconstruction of the optical and dynamic properties of turbid media.
Uniqueness of the Solution
- Multiple optical line sources are positioned around the turbid medium like human and animal tissue, blood, milk, etc. which illuminate the medium from different angles. This system eliminates the need for scanning the sample which simplifies the instrumentation and improves temporal resolution.
- The system is configured to reconstruct the three-dimensional optical and dynamic properties of the turbid media using a two-dimensional media captured by the detector.
- A camera can be employed as a detector to quantify speckle contrast since this method increases signal-to-noise ratio, and allows deep imaging with inexpensive detectors.
- The system compensates for the decay rate bias of a single optical line source by using multiple sources and improves temporal resolution.
- It increases the number of photons and effective area within biosafety limits for in-vivo imaging which increases detection area of the detector without changing dynamic range.
Prototype Details
- This has been tested in a lab environment
- Change flow/Brownian motion is reconstructed using this system. Using previous techniques the imaging is relatively biased towards the source as compared to this method.
- The blood flow in mice brain with skull intact has been shown with a good SNR.
- Speckle contrast at T = 1ms and the arteries/veins segmented from the binarized speckle contrast has been shown.
Current Status of Technology
TRL 4
Technology readiness level
4
Societal Impact
- By reducing complex instrumentation, it can be used in remote areas with less technical facilities
- Improved image quality even while using a normal camera which eliminates the need for costly detectors
Relevant Industries, Domains and Applications
Medical imaging, Biotechnology, Pharmaceutical, Material Science
Applications or Domain
- The system can be used for reconstructing tissue properties, like concentration of oxyhaemoglobin, deoxyhaemoglobin, level of oxygen saturation, flow of blood.
- It can be used for surface blood flow measurements after increasing the area of illumination.
Application Number
202221000156
Filing Date
Grant Number
408929
Grant Date
Assignee(s)
Indian Institute of Technology Bombay