This invention presents a novel and efficient process for synthesizing 6-deoxy-L-alloside starting from L-rhamnose. The process involves a series of regioselective protections, triflation, and nucleophilic displacement reactions to transform L-rhamnose into valuable 6-deoxy-L-sugar derivatives like 6-deoxy-L-alloside.
The commercial availability of 6-deoxy-L-sugars is limited, with only L-rhamnose and L-fucose readily accessible. The current methods for synthesizing rare sugars like 6-deoxy-L-alloside are complex, inefficient, and involve multiple protection and deprotection steps, resulting in low yields and high production costs.
- Regioselective protection of hydroxyl groups in L-Rhamnose
- Triflation and nitrite anion-mediated inversion techniques
- Cascade inversions for the synthesis of 6-deoxy-L-hexoses
- Streamlined synthesis process for 6-deoxy-L-hexoses
- Utilizes inexpensive and readily available L-rhamnose
- Improves overall yield and efficiency compared to existing methods
- Cost-effective production suitable for industrial applications
The prototype involves a step-by-step synthesis process starting from L-Rhamnose, employing selective protection, triflation, and inversion reactions to produce 6-deoxy-L-alloside in higher yields.
The process has been successfully developed and demonstrated at the laboratory scale, with potential for scaling up for industrial production.
This technology reduces production costs and increases the availability of rare sugars, leading to more affordable pharmaceuticals, and greatly impacting the biotechnology industries, thereby improving public health and contributing to economic growth.
It has applications in pharmaceutical industry, biotechnology, chemical manufacturing, agricultural biotechnology, such as the following:
- Synthesis of components for antibiotics, antitumor agents, and glycopeptides
- Production of biologically active glycosides used in various therapeutic treatments
- Development of new chemical pathways for sugar derivatives
- Potential use in the synthesis of bioactive compounds for plant protection and growth
Geography of IP
Type of IP
202122003643
417359