Synthesis of N2-Furfuryl Deoxyguanosine Phosphoramidite and Modified Oligonucleotides

N²-furfuryl deoxyguanosine phosphoramidite compound of formula 4 is provided which are building blocks for synthesis of modified DNA.

A process of synthesis of N²-furfuryl eoxyguanosine phosphoramidite is also provided which is safe and economically viable. The modified amidite has been successfully incorporated into oligonucleotides by solid phase DNA synthesis.