A novel and inexpensive design for establishing flow rates in Simulated Moving Bed Chromatography (SMBC) system

The present invention relates to simulated moving bed chromatographic apparatus capable of implementing non-steady state operations by dynamically switching flow rates from one node to the next thus efficiently separating different components of a mixture dissolved in liquid medium based on adsorption affinities of each component. The apparatus maintains the internal flow rate by pumping desired amount of mobile phase into each column.