Asymmetric synthesis of γ-nitrophosphonates in the absence of any other chiral catalysts

Last few decades have seen development of chiral catalysis to an extent where it can be thought of biomimicking. However, source of pure enantiomer still beholds in the technique of classic resolution, biochemical and biological methods. This is due to the fact that most of the asymmetric reactions are not absolute in the sense of selectivity. The present invention envisages that the autocatalytic amplification can be critical leading to the utilization of general reactions where enantiomeric excess is anything but absolute. The exclusion of external ligand for catalysis save costs to a great extent and also removes the necessity to separate the product from catalyst which could further prove economical in commercial applications.

Faculty Associated


  • Irishi N N Namboothiri, Vishal Rai\t

Patent Application no.