Development of nanoengineered dual release graft for pain /inflammation management in osteoarthritis

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Osteoarthritis (OA) is a chronic degenerative disorder of joints, which has multi- factorial etiology. OA is the second most common rheumatological problem and is most frequent joint disease with prevalence of 22-39% in India. Injectable polymeric composite gel are synthesised with tailor-made polymeric nanoparticles to achieve both controlled release and thermo-responsive on application of a heat pad on the desired site. The main objective of the project is to develop an intra- articular drug delivery system for OA using a composite in situ gelling system. This system is designed in such a way that it can deliver an anti-inflammatory drug in a sustained/controlled manner, and a pain-relieving agent on response to application of heat. The composite in situ gelling system comprise of a thermoresponsive in situ gel made of chitosan.